SSRIs are basically medications used to help with psychological conditions, specifically depression and anxiety. The use of marijuana with this can sometimes create some side effects such as dry mouth, sleep issues, and dizziness. This may have some moderate interactions, however. medical cannabis is also used to help with the intake of antidepressants though, and also headaches, appetite issues, and also insomnia too. While depression is sometimes a big part of anxiety, you can use medical cannabis to help with this. 

So what are they? 

These are basically a class of different antidepressants that use serotonin noradrenaline reuptake inhibitors, and it’s similar to other antidepressants. 

Some of the most common are the following: – Prozac 

• Oxactin 
• Cipramil 
• Prilligy 
• Cipralex 
• Seroxat 
• Lustral 
• Brintellix 

These work in a way to help increase your serotonin in the body on the extracellular level.  This also limits the resorption that happens in the presynaptic cells, to increase such. 

This is something that’s strong in affinity with the serotonin transporters, but it’s weak for dopamine and norepinephrine, so it can actually help with interacting that. It also is good for helping to start action in your sigma receptors. Fluvoxamine is another major agonist, and setaeline is an antagonist of that receptor, and paroxetine doesn’t interact significantly with the other receptors. 

There isn’t one specific mechanism for this, and instead it can be used for a variety of different situations. That’s because our brain chemistry is way too complex to be a one-size-fits-all sort of thing. They also may take a bit to work, and sometimes, they don’t work for everyone. 

It can sometimes cause issues with the synapses, but over time, it starts to get a bit better. 

They also can help with other problems including PTSD, eating disorders, or even Social Anxiety Disorder.  It can work for OCD and chronic pain too. 

The benefits and Drawbacks 

The problem with cannabis s that there are cannabinoids within the compound itself that inhibit the P2C19 enzymes, which means that it can sometimes cause problems with metabolizing them. 

Not to mention that CBD does modulate the serotonin in this, and THC also activates the receptors that inhibit serotonin, impacting uptake.  That also means that it can cause problems with the issues that are assumed with cannabis along with SSRIs. However, mixing this can help with getting relief immediately for depression and anxiety.  This also can act directly on the serotonin receptors in particular. 

It also can help with managing different side effects that come with this, including antidepressant uptake, helps with headaches, appetite issues, nausea, GI issues, and insomnia. There is also a chance that it can reduce the antidepressants needed, and some people who don’t like antidepressants may use this, since it’s not as addiction-risking in a lot of cases. 

Plus, cannabis has a lot of natural stress-boosting aspects to this, including limonene, pinene, along with linalool. The risk however are definitely worth mentioning. Dosage is a big part of this, since cannabis can be potent as a natural antidepressant, and if you take too much, it can make this worse. 

High levels of THC do deplete your serotonin, which is why you may feel more depressed especially if you take too much. It can also impair how your liver metabolizes all of this. There is also a rare instance of serotonin syndrome, which is something that can come about because of too much cannabis with antidepressants. 

It’s best to make sure tat if you use this, you’re mindful of the effects, and if they get bad, stop taking them immediately for your benefits.