IBD, or inflammatory bowel disease, is basically a condition that’s not fun for a lot of people. It causes inflammation, bleeding, pain, diarrhea, tiredness, loss in weight, and it’s a major problem. The thing with this, is you have three major types—ulcerative colitis, Crohn’s disease, and also indeterminate bowel disease. This is something that’s distinguished by the location of this, and some of the symptoms. It’s not totally clear about how this comes about diet, smoking, pollution, and even genetics may play a part in it, since it’s attributed to gut bacteria.
The scary thing is that this is increasing a lot in various countries and such, and currently, the main medical treatment includes steroids, aminoacylates, biologics, and immunomodulating drugs that can help with the pain. sometimes, you might get surgery too, where part of your gut is removed.
The problem is though, up to 40% of people with this actually don’t do well with treatment, and about half of them stop responding during the maintenance periods. This also doesn’t stop the possibility of colon cancer either. That’s why many are using alternatives, including cannabis, to help with this.
ECS and your gut
The ECS, or endocannabinoid system, is basically an evenly-distributed system all throughout various parts of your body, and it’s involved and does a lot for you. It involves the circulation of different cannabinoids, enzymes, and also helps regulate aspects of different parts of the body, including your gut.
Some experiments have perform and different results on this, especially in those animals that are treated for IBD by looking at the ECS. Some studies actually saw major changes in inflammation of the gut, and some actually found that the colons weren’t as inflamed as before, and it suggests a link between the ECS, and your gut microbiome.

There are other animal studies too, where cannabinoids from plants actually helped to activate your ECS, and it did prove that there was less secretions, gut motility, inflammation, and it boosted the activation of the immune system, and it also showed that it activated your CB1 receptors, and also did decrease your motility and bowel tone, and it also showed that it reduced the release of various chemicals that are inflammatory from various immune aspects.
Studies of CBD for IBD
There are also some studies that have tried to use CBD for this. While THC does have some studies that show the motility of the gut did get better, CBD is better for helping with the immunomodulatory of the gut, and also reduced inflammation in the animal studies that were there.
However, it was found that THC is good for colon health, stimulating the mucus in there, improving the good bacteria by also making sure that it did work with the immune and gut cells to help with inflammation.
In some studies that were done in 2021, they used randomized, double-blind, placebo trials in over 30 people that had UC, and 56 different people who had CD, and it was found that the cannabis in this improve their quality of life and they had beneficial effects that weren’t directly a part of the inflammatory improvements.

It was also found that a quarter of these respondents were also noticing less pain in their abdominal area, less cramping, sleep issues, and also anxiety, and it helped with the management of various symptoms of IBD, and also helped a lot more, especially for long-term users.
It’s clear that with this, cannabis can help with a variety of conditions, including treatment for IBD, and might be a better alternative to typical treatments.

